UPDATE (4:39 p.m.): CHP has reopened he intersection at Garces Highway and Highway 43 following the crash.
CHP says two people in the pickup truck were taken to Kern Medical with major injuries.
Caltrans has closed Highway 43 at Garces Highway because of a crash. CHP reports the crash involved a semi truck and a pickup truck.
The crash was first reported at 3:16 p.m. according to CHP Traffic Incident Information Page.
We will update this story as we learn more information.