WebMD Medical News
Louise Chang, MD
Oct. 26, 2009 -- A new, four-drug regimen to wipe out bacteria associated
peptic ulcers and stomach
inflammation banished the bugs better than the standard three-drug treatment
often used, according to research presented at ACG 2009, the annual meeting of
the American College of Gastroenterology in San Diego.
The new, four-drug treatment is "tolerable, and there is excellent
compliance," says researcher P. Patrick Basu, MD, an assistant professor of
medicine at Columbia University College of Physicians and Surgeons, New York,
and chief of the division of gastroenterology and endoscopy at North Shore
University Hospital at Forest Hills, N.Y.
Unchecked, the bacteria
Helicobacter pylori can lead to irritation of the stomach lining and
inflammation of the lining (gastritis)
and peptic ulcers, and boost the risk for certain types of stomach
An estimated 40% of U.S. residents are infected with H. pylori,
according to Basu, but most have no problems with it. Those who are bothered
may report a burning pain in the abdomen,
nausea, vomiting, burping,
bloating, and weight loss.
When the symptoms are bad enough, they prompt a visit to the doctor, who may
order a test for the bacteria. The bacteria are detected in a number of ways,
including a blood test that looks for antibodies in the blood to indicate
exposure, a stool test that looks for evidence of infection, a breath test that
checks for the presence of a gas the bacteria produces, or other ways.
Once the bacteria are found in those with troublesome symptoms, the goal is
to eradicate them to avoid future problems. Several drug treatment approaches
are available, but compliance is often poor, experts say, and the bacteria
aren't always eliminated. Resistance to the antibiotics is sometimes a problem,
Basu and his colleagues compared a new four-drug regimen -- a seven-day
course and a 10-day course -- with a standard 10-day, three-drug treatment. The
study was not funded by any drug company.
The three-drug regimen, a standard approach, is called LAC because it
The four-drug regimen, called LOAD, included:
In all, 135 patients were evaluated, with 45 in each of the three regimens.
The average age in all three groups was 46. Some had peptic ulcers, others had
gastritis or other gastric conditions linked to the bacteria. All had been off
antibiotic or PPI use for six weeks before beginning the new ulcer treatments.
None had undergone treatment to eradicate H. pylori before.
The four-drug approach eliminated bacteria in more than 95% of all these
patients, with the seven-day plan achieving it in 95.3% and the 10-day 95.2%.
The three-day approach eliminated it in 80.9%. Physicians say compliance is
often a problem, with patients not taking prescribed pills, but Basu found high
compliance, with 93.3% of the 10-day LOAD patients and the 10-day LAC patients
completing the treatment and 95.6% of the LOAD seven-day patients
When the analysis was computed to include everyone who began the study,
including the eight who discontinued the treatments, the four-drug, seven-day
plan eliminated bacteria in 91.1%, the four-drug 10-day plan eliminated it in
88.9%, and the three-drug, 10-day plan eradicated bacteria in 75.6%.
Side effects reported by all groups were mostly minor, such as headache,
All patients he studied had not received treatment before, so Basu can't yet
say whether the new plan might be worth a try for those who have failed
Costs are comparable, Basu says. "LAC is about $400 for 10 days, and LOAD is
about $400 for seven days. LOAD 10 is about $535."
''It's a completely new regimen," says William Chey, MD, professor of
medicine at the University of Michigan, Ann Arbor, who reviewed the study
findings for WebMD.
He views the results as promising. "This is exciting news about a potential
new therapy," he says. New treatment regimens have been few in recent years, he
says, as the percentage of people with H. pylori in the U.S. has dropped
What strengthens the study finding that the four-day approach is more
effective, he says, is that "the eradication rate he got with [the three-day
approach] is exactly what you would expect based on other studies from the
U.S." In his recent review of published studies, Chey found an eradication rate
of about 77% with three-drug treatment plans, close to the 80% found in the new
Physicians should consider the new four-drug regimen, he says, adding that
further studies are needed. "The results are encouraging, and the eradication
rates with standard therapy are not very good."
SOURCES:P. Patrick Basu, MD, assistant professor of medicine and chief of the
division of gastroenterology and endoscopy, North Shore University Hospital,
Forrest Hills, N.Y.ACG 2009, annual meeting of the American College of Gastroenterology, San
Diego, Oct. 23-28, 2009.William Chey, MD, professor of medicine, University of Michigan, Ann
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