San Diego, CA (Sports Network) - Pablo Sandoval went 2-for-4 and smacked the game-winning homer in the top of the 10th inning to lift the San Francisco Giants over the San Diego Padres, 4-3, in the season finale for both clubs.

Ryan Webb (2-1) started the top of the 10th for the Padres and was greeted with Sandoval's blast to center.

"It was fitting that he hit the home run to win the ballgame for us," Giants manager Bruce Bochy said. "These guys came out on the last day and played hard, I'm proud of them. It was a great finish for us."

Juan Uribe knocked in a run for the Giants (88-74), who finished the season third in the National League West. Eugenio Velez went 3-for-5 with a pair of runs scored. Andres Torres had two hits for San Fran, which hasn't made the postseason since the 2003 campaign.

Jonathan Sanchez went 5 1/3 innings in the start, allowing two runs on three hits with four walks and three strikeouts. He finished the season with an 8-12 record and a 4.24 ERA. Jeremy Affeldt (2-2) tossed two scoreless frames of relief to get the win. Brian Wilson got out of a first-and-second jam in the bottom of the 10th to pick up his 38th save of the year.

Randy Johnson, in possibly his final season of his 22-year career, had a pair of strikeouts while pitching the seventh inning.

David Eckstein belted a two-run homer for the Padres (75-87), who finished fourth in the NL West.

Cesar Ramos lasted 4 1/3 frames, giving up three runs on nine hits with three strikeouts. He ended the season with an 0-1 record and a 3.07 ERA.

"I felt all right," Ramos said. "I didn't have my best stuff. Luckily, my offspeed saved me today, those couple tough innings. Just gave it what I had and kept us in the game."

The Giants jumped out to an early lead with a run in the first inning. Velez led off with a single, Torres reached base on a bunt single, and Sandoval singled to load the bases. Velez scored when Uribe grounded into a double play.

The Padres failed to score after putting their first two men on base in the second.

San Francisco plated a pair of runs in the third to build a three-run margin. Singles from Sanchez, Velez, and Torres loaded the bases. Sandoval then drove in a run when he grounded into a double play. Uribe followed with an RBI double. Uribe was thrown out at the plate on Ryan Garko's base hit.

Eckstein's two-run homer in the sixth cut the deficit to 3-2. Everth Cabrera hit a one-out single before Eckstein deposited a Sanchez offering over the wall in left.

San Diego scored a run in the seventh to deadlock the tilt. With the bases loaded and one out, Nick Hundley scored on an Eckstein foul out to third.

Neither team scored over the final few frames to send the tilt into extras.